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KMID : 0931320060060010029
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대한상부위장관.헬리코박터학회지
2006 Volume.6 No. 1 p.29 ~ p.34
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Promoter Methylation of Helicase-like Transcription Factor in Gastric Cancer
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Song Ji-Hyun
Kim Jung-Hwan
Shim Sang-Goon
Kim Sung
Song Sang-Yong
Kim Duk-Hwan
Kim Jae-Jun
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Abstract
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Background/Aims: To investigate the significance of promoter methylation of the helicase-like transcription factor (HLTF) in primary gastric cancer.
Methods: 256 gastric cancer patients participated in this study. HLTF methylation status was evaluated by the methylation-specific polymerase chain reaction.
Results: HLTF methylation was found in 38% of the patients and associated with family history in the early stage of gastric cancer. In intestinal-type, HLTF methylation occurred in 56% of patients with family histories, and in 31% without family histories. In diffuse-type, patients with family histories were also shown a higher prevalence of HLTF methylation than those without family histories (61% vs. 34%). HLTF methylation occurred in about 70∼90% of the early stage with family histories and in 15∼30% without family histories.
Conslusions: HLTF methylation may play a crucial role in the early stage of gastric carcinogenesis in patients with family histories and may be a valuable susceptible marker for the risk of gastric cancer in individuals with family histories. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2006;6:29-34)
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KEYWORD
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HLTF, Methylation, Gastric cancer, Family history
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